Excoecaria agallocha is a medicinal mangrove abundantly distributed in Southeast coast of India with absence of alkaloid scientific evidence. Therefore, the present study aimed to evaluate their radical scavenging effect and identify the alkaloids from crude alkaloids fraction of E.agallocha leaves using GC-MS analysis. The crude alkaloid fraction was isolated from 30 g powdered leaves of Excoecaria agallocha through acid-base method and subjected to GC-MS analysis. The alkaloid rich fractions confirmed radical scavenging activity with 88.85 ± 0.196 for 10 ppm. GC-MS results identify 21 phyto-constituents, include 12 alkaloid derivatives are 1-[a-(1-Adamantyl) benzyl idene] thio, Propanamide, Benzene methanol, 2-(2-aminopropoxy, 2-5-Dimethoxy-4-(methylthionyl), 1-Amino-2-(hydroxymethyl) anthraquinine, DL-Cystine, 2-Propen-1-one, 3-(4-nitrophenyl)-, Phenylephrine and 5 higher alkanes viz., Hexadecane, Tetradecane, Pentadecane and Heptaflurobutyric acid acids/alcohols are present in significant concentration. However, the bioactivity of individual alkaloid may proceed to find a novel drug after implications with preclinical studies.
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